Landslide susceptibility mapping is considered as the first important step in landslide risk assessment. The main purpose of this study is to compare the performance of a machine learning algorithm (a logistic model tree), and a statistical model (a logistic regression), for landslide susceptibility modeling in the Sarkhoon watershed, Chaharmahal and Bakhtiari province. For this purpose, at first, a landslide inventory map including a total of 98 landslide locations was constructed using historical landslides, and extensive field surveys. In addition, a total of 100 non-landslide locations were also identified to construct a database. The landslide and non-landslide locations were randomly selected and divided into two groups with a 70/30 ratio for modelling and validation processes. Twenty conditioning factors were selected based on literature review and geo-environmental properties in the study area. Subsequently, the logistic model tree (LMT) and the logistic regression (LR) models were applied to identify the influence of conditioning factors on landslide occurrence. Finally, the performance of the models in landslide susceptibility mapping was investigated using the area under the receiver operating characteristics curve (AUC). The results concluded that the LR model (AUC = 0.797) outperformed and outclassed the LMT (AUC = 0.740) model in the study area. Although both models were reliable tools for spatial prediction of landslide susceptibility; however, the LR model was more accurate that it can be proposed as an alternative tool for better management of areas prone to landslide in the study area.